Doe Lab

University of Oregon | Institute of Neuroscience | Institute of Molecular Biology | Howard Hughes Medical Institute | Eugene, OR

Recent Publications

 

 

2013

Carney TD, Struck AJ, Doe CQ. (2013) midlife crisis encodes a conserved zinc-finger protein required to maintain neuronal differentiation in Drosophila. Development ePress 11 September 2013 | [PDF]

Johnston CA, Manning L, Lu MS, Golub O, Doe CQ, Prehoda KE. (2013) Formin-mediated actin polymerization cooperates with Mud/Dynein during Frizzled/Dishevelled spindle orientation. Journal of Cell Science July 18. (Epub ahead of print). PMID:23868974 | [PDF]

Bayraktar OA, Doe CQ. (2013) Combinatorial temporal patterning in progenitors expands neural diversity. Nature Jun 27;498(7455):449-55. PMID: 23783519 | [PDF]

Kohwi, M., Lupton, J.R., Lai, S-L., Miller, M.R., Doe, C.Q. (2013) Developmentally Regulated Subnuclear Genome Reorganization Restricts Neural Progenitor Competence in Drosophila. Cell January 17, 2013; 152 97-108. PMCID: PMC3670710| [PDF]

Gay, L., Miller, M.R., Ventura, P.B., Devasthali, V., Vue, Z., Thompson, H.L., Temple, S., Zong, H., Cleary, M.D., Stankunas, K., Doe, C.Q. (2013) Mouse TU tagging: a chemical/genetic intersectional method for purifying cell type-specific nascent RNA. Genes & Development January 1, 2013; 27 (1) 98-115. PMCID: PMC3553287 | [PDF]

2012

Lai, S-L, Miller, M.R., Robinson, K.J., Doe, C.Q. (2012) The snail family member worniu is continuously required in neuroblasts to prevent elav-induced premature differentiation. Developmental Cell Oct 16;23(4):849-57. PMCID: PMC3509944 | [PDF]

Manning, L., Heckscher, E.S., Purice, M.D., Roberts, J., Bennett, A.L., Kroll, J.R., Pollard, J.L., Strader, M.E., Lupton, J.R., Dyukareva, A.V., Doan, P.N., Bauer, D.M., Wilbur, A.N., Tanner, S., Kelly, J.J., Lai, S-L, Tran, K.D., Kohwi, M., Laverty, T.R., Pearson, J.C., Crews, S.T., Rubin, G.M., Doe, C.Q. (2012) A Resource for Manipulating Gene Expression and Analyzing cis-Regulatory Modules in the Drosophils CNS. Cell Reports Oct 25;2(4):1002-13 | [PDF]

Heckscher, E.S., Lockery, S.R., Doe, C.Q. (2012) Characterization of Drosophila larval crawling at the level of organism, segment, and somatic body wall musculature. Journal of Neuroscience Sept 5;32(36):12461-71. | [PDF]

Johnston, C.A., Doe, C.Q., Prehoda, K.E. (2012) Structure of an enzyme-derived phosphoprotein recognition domain. PLoS One Vol. 7 (4) e36014. PMCID: PMC3335814 | [PDF]

Miller, M.R., Brunelli, J.P., Wheeler, P.A., Liu, S., Rexroad III, C.E., Palti, Y., Doe, C.Q., Thorgaard, G.H. (2012) A conserved haplotype controls parallel adaptation in geographically distant salmonid populations. Molecular Ecology 21, 237-249. | [PDF]

Andersen, R.O., Turnbull, D.W., Johnson, E.A., Doe, C.Q., (2012) Sgt1 acts via an LKB1/AMPK pathway to establish cortical polarity in larval neuroblasts. Developmental Biology 363, 258-265. | [PDF]

Sun, K., Westholm, J.O., Tsurudome, K., Hagen, J.W., Lu, Y., Kohwi, M., Betel, D., Gao, F-B., Haghighi, A.P., Doe, C.Q., Lai, E.C. (2012) Neurophysiological Defects and Neuronal Gene Deregulation inDrosophila mir-124 Mutants. PLos Genetics V8 (2) e1002515. PMCID: PMC3276548 | [PDF]

Carney, T.D., Miller, M.R., Robinson, K.J., Bayraktar, O.A., Osterhout, J.A., Doe, C.Q. (2012) Functional genomics identifies neural stem cell sub-type expression profiles and genes regulating neuroblast homeostasis. Developmental Biology 361, 137-146. PMCID: PMC3553287 | [PDF]

2011

Connell, M., Cabernard, C., Ricketson, D., Doe, C.Q. Prehoda, K.E. (2011) Asymmetric cortical extension shifts cleavage furrow position in Drosophila neuroblasts. Molecular Biology of the Cell V22, 4220-4226. PMCID: PMC3216648 | [PDF]

Johnston, C.A., Whitney, D.S., Volkman, B.R., Doe, C.Q., Prehoda, K.E. (2011) Conversion of the enzyme guanylate kinase into a mitotic-spindle orienting protein by a single mutation that inhibits GMP-induced closing. PNAS 108 (44), E973-E978. PMCID: PMC3207680 | [PDF]

Wee, B., Johnston, C.A., Prehoda, K.E., Doe, C.Q. (2011) Canoe binds RanGTP to promote PinsTPR/mud-mediated spindle orientation. The Journal of Cell Biology V195 (3), 369-376. PMCID: PMC3206335 | [PDF]

Hirono, K., Margolis, J.S., Posakony, J.W.. Doe, C.Q. (2011) Identification of hunchback cis-regulatory DNA conferring temporal expression in neuroblasts and neurons. Gene Expression Patterns 12, 11-17. PMCID: PMC3272097| [PDF]

Faumont, S., Rondeau, G., Thiele, T.R., Lawton. K., McCormick, K.E., Sottile, M., Griesbeck, O., Heckscher, E.S., Roberts, W.M., Doe, C.Q., Lockery, S.R. (2011) An Image-Free Opto-Mechanical System for Creating Virtual Environments and Imaging Neuronal Activity in Freely Moving Caenorhabditis elegans. PLoS one V6(9) e24666 PMCID: PMC3182168 | [PDF]

Doe, C.Q., Kaibuchi, K., (2011) Neuronal Polarity in 2011. Developmental Neurobiology 71(6), 401-402. | [PDF]

Kohwi, M., Hiebert, L.S., Doe, C.Q., (2011) The pipsqueak-domain proteins Distal antenna and DIstal antenna-related restrict Hunchback neuroblast expression and early-born neuronal identity. Development 138, 1727-1735. PMCID: PMC3074449 | [PDF]

2010

Segalen, M., Johnston, C.A., Martin, C.A., Dumortier, J.G., Prehoda, K.E., David, N.B., Doe, C.Q., Bellaiche, Y., (2010) The Fz-Dsh Planar Cell Polarity Pathway Induces Oriented Cell Division via Mud/NuMA in Drosophila and Zebrafish. Developmental Cell 19, 740-752. | [PDF]

Bayraktar, O.A., Boone, J.Q., Drummond, M.L., Doe, C.Q., (2010) Drosophila type II neuroblast lineages keep Prospero levels low to generate large clones that contribute to the adult brain central complex. Neural Development October 1, 5;26 | [PDF]

Cabernard, C., Prehoda, K.E., Doe, C.Q., (2010) A spindle-indepedent cleavage furrow positioning pathway. Nature Vol 467, 2 September, 91-95. | [PDF]

Callan, MA, Cabrnard C, Heck J, Louis S, Doe CQ, Zarnescu DC., (2010) Fragile X protein controls neural stem cell proliferation in the Drosophila brain. Human Molecular Genetics Aug 1;19(15):3068-79. | [PDF]

Tran, K.D., Miller, M.R., Doe, C.Q., (2010) Recombineering Hunchback identifies two conserved domains required to maintain neuroblast competence and specify early-born neuronal identity. Development 137(9), 1421-1430. | [PDF]

2009

Kohwi, M., Doe, C.Q., (2009) Preview, Stem cell transcriptional loops generate precise temporal identity. Cell Stem Cell Dec. 4;5(6):577-578. | [PDF]

Siller, K.H., Doe, C.Q., (2009) Spindle orientation during asymmetric cell division. Nature Cell Biology April V.11(3): 365-374. | [PDF]

Marcette, J., Hood, I.V., Johnston, C.A., Doe, C.Q., Prehoda, K.E., (2009) Allosteric Control of Regulated Scaffolding in Membrane-Associated Guanylate Kinases. Biochemistry 48, 10014-10019. | [PDF]

Miller, M.R., Robinson, K.J., Cleary, M.D., Doe, C.Q., (2009) TU-tagging: cell type-specific RNA isolation from intact complex tissues. Nature Methods 6, 439-441. | [PDF]

Cabernard, C., Doe, C.Q., (2009) Apical/Basal Spindle Orientation is Required for Neuroblast Homeostasis and Neuronal Differentiation in Drosophila. Developmental Cell 17, 134-141. | [PDF]

Johnston, C.A., Hirono, K., Prehoda, K.E., Doe, C.Q. (2009) Identification of an Aurora-A/PinsLINKER/Dlg Spindle Orientation Pathway using Induced Cell Polarity in S2 Cells. Cell 138, 1150-1163.| [PDF]

Chabu, C, Doe, C.Q., (2009) Twins/PP2A regulates aPKC to control neuroblast cell polarity and self-renewal. Developmental Biology 330, 399-405. | [PDF]

2008

Tran, K.D., Doe, C.Q., (2008) Pdm and Castor close successive temporal identity windows in the NB-3 lineage. Development 135, 3491-3499. | [PDF]

Chabu, C., Doe, C.Q., (2008) Dap160/intersectin binds and activates aPKC to regulate cell polarity an cell cycle progression. Development 135, 2739-2746. | [PDF]

Siller, K.H., Doe, C.Q., (2008) Lis1/dynactin regulates metaphase spindle orientation in Drosophila neuroblasts. Developmental Biology 319, 1-9. | [PDF]

Boone, J.Q., Doe, C.Q., (2008) Identification of Drosophila Type II Neuroblast Lineages Containing Transit Amplifying Ganglion Mother Cells. Developmental Neurobiology 69, 1185-1195. | [PDF]

Doe, C.Q., (2008) Neural stem cells: balancing self-renewal with differentiation. Development 135, 1575-1587. | [PDF]

Zhu, C.C., Boone, J.Q., Jensen, P.A., Hanna, S., Pdemski, L., Locke, J., Doe, C.Q., O'Connor, M., (2008) Drosopila Activin-ß and the Activin-like product Dawdle function redundantly to regulate proliferation in the larvel brain. Development 135, 513-521. | [PDF]

Pfeiffer, B.D., Jennett, A., Hammonds, A.S., Ngo, T.B., Misra, S., Murphy, C., Scully, A., Carlson, J.W., Wan, K.H., Laverty, T.R., Mungall, C., Scirskas, R., Kadonaga, J.T., Doe, C.Q., Eisen, M.B., Celniker, S.E., Rubin, G.M., (2008). Tools for neuroanatomy and neurogenetics in Drosophila. PNAS Vol. 105 (28), 9715-9720. | [PDF]

2007

Atwood, S.X., Chabu, C., Penkert, R.R., Doe, C.Q., Prehoda, K.E., (2007) Cdc42 acts downstream of Bazooka to regulate neuroblast polarity through Par-6-aPKC. Journal of Cell Science 120, 3200-3206. | [PDF]

Nipper, R.W., Siller, K.H., Smith, N.R., Doe, C.Q.. Prehods, K.E., (2007) G alpha i generates multiple Pins activation states to link cortical polarity and spindle orientation in Drosophila neuroblasts. PNAS 104 (36), 14306-14311. | [PDF]

Cabernard, C., Doe, C.Q. (2007) Stem Cell Self-Renewal: Centrsomes on the Move. Current Biology 17: R465-R467. | [PDF]

Rolls, M.M., Satoh, D., Clyne, P.J., Henner, A.L., Uemura, T., Doe, CQ (2007) Polarity and intracellular compartmentalization of Drosophila neurons. Neural Development Apr 30;2(1):7 | [PDF]

Siegrist, S.E., Doe, C.Q. (2007) Microtubule-induced cortical cell polarity. Genes & Development Mar 1;21(5):483-96 | [PDF]

Egger, B.,Boone, J.Q., Stevens, N.R., Brand, A.H., Doe, C.Q. (2007) Regulation of spindle orientation and neural stem cell fate in the Drosophila optic lobe. Neural Development Jan 5;2:1 | [PDF]

2006

Lee, C-Y, Andersen, R.O., Cabernard, C., Manning, L., Tran, K.D., Lanskey, M.J., Bashirullah, A., Doe, C.Q. (2006) Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation. Genes & Development 20 (24), 3464-3474 | [PDF]

Doe, C.Q. (2006) Chinmo and neuroblast temporal identity. Cell Oct 20;127(2):254-6 | [PDF]

Grosskortenhaus, R., Robinson, K.J., Doe, C.Q. (2006) Pdm and Castor specify late-born motor neuron identity in the NB7-1 lineage. Genes & Development Sep 15;20(18):2618-27 | [PDF]

Siller, K.H., Cabernard, C., Doe, C.Q. (2006) The NuMA-related Mud protein binds Pins and regulates spindle orientation in Drosophila neuroblasts. Nature Cell Biology Jun;8(6):594-600 | [PDF]

Lee, C-Y., Wilkinson, B.D., Siegrist, S., Wharton, R., Doe, C.Q. (2006) Brat Is a Miranda Cargo Protein that Promotes Neuronal Differentiation and Inhibits Neuroblast Self-Renewal. Developmental Cell 10, 441-449 | [PDF]

Cleary M., Doe C.Q. (2006) Regulation of neuroblast competence: multiple temporal identity factors specify distinct neuronal fates within a single early competence window. Genes & Development 20:429-434 | [PDF]

Layden M.J., Odden J., Schmid A., Garces A., Thor S., Doe CQ, (2006) Zfh1, a somatic motor neuron transcription factor, regulates axon exit from the CNS. Developmental Biology 291:253-263 | [PDF]

Siegrist, S.E., Doe, C.Q. (2006) Extrinsic cues orient the cell division axis in Drosophila embryonic neuroblasts. Development Feb 133(3):529-36 | [PDF]

Lee C-Y., Robinson K., Doe C.Q. (2006) Lgl, Pins and aPKC regulate neuroblast self-renewal versus differentiation. Nature 439(2) 594-598 | [PDF]

2005

Siegrist S., Doe C.Q. (2005) Microtubule-Induced Pins/Gai Cortical Polarity in Drosophila Neuroblasts. Cell 123:1323-1335 | [PDF]

Siller K., Serr M., Steward R., Hays T.S., Doe C.Q. (2005) Live Imaging of Drosophila Brain Neuroblasts Reveals a Role for Lis1/Dynactin in Spindle Assembly and Mitotic Checkpoint Control. Molecular Biology of the Cell 16;5127-5140 | [PDF]

Armstrong, J.A., Sperling, A.S., Deuring, R., Manning, L., Moseley, S.L., Papoulas, O., Piatek, C.I., Doe, C.Q., Tamkun, J.W. (2005) Genetic screens for enhancers of brahma reveal functional interactions between the BRM chromatin-remodeling complex and the delta-notch signal transduction pathway in Drosophila. Genetics Aug 170(4):1761-74 | [PDF]

Grosskortenhaus R, Pearson BJ, Marusich A, Doe C.Q. (2005) Regulation of temporal identity transitions in Drosophila neuroblasts. Developmental Cell. 2005 Feb;8(2):193-202 | [PDF]

Karcavich, R. and Doe, C.Q. (2005) The Drosophila neuroblast 7-3 cell lineage: a model system for studying programmed cell death, Notch/Numb signaling, and sequential specification of GMC identity. The Journal of Comparative Neurology, 481:240-251 | [PDF]

2004

Cheesman, S., Layden, M., von Ohlen, T., Doe, C.Q. and Eisen, J.S. (2004) Zebrafish and fly Nkx6 proteins have similar CNS expression patterns and regulate motoneuron formation. Development 131 5221-5232. | [PDF]

Pearson, B., Doe, C.Q. (2004) Specification of temporal identity in the developing nervous system. Annual Review of Cell and Developmental Biology, Vol. 20, pages 619-647. | [PDF]

Rolls, M.M. and and Doe, C.Q. Baz, (2004) Par-6 and aPKC are polarized in mature neurons, but are not required for in vivo axon specification in Drosophila. Nature Neuroscience., 421, 905-906. | [PDF]

Irion, U., Leptin, M., Siller, K., Fuerstenberg, S., Cai, Y., Doe, C.Q., Chia, W., and Yang, X. (2004) Abstrakt, a DEAD box protein, regulates inscuteable at a post-transcriptional level and is required for asymmetric division of neural and mesodermal progenitors. Current Biology, 14, 138-144. | [PDF]

Isshiki, T. and Doe, C.Q. (2004) Youthfulness of neural progenitors in Drosophila. Cell Cycle, 3, 296-299. | [PDF]

2003

Albertson, R., Chabu, C., Sheehan, A. and Doe, C.Q. (2003) Scribble protein domain mapping reveals a multistep localization mechanism and domains necessary for establishing cortical polarity. Journal of Cell Science 117, 6061-6070. | [PDF]

Pearson, B. and Doe, C.Q. (2003) Regulation of neuroblast competence in Drosophila. Nature, 425, 624-628 | [PDF] [Movie 1] [Movie 2]

Freeman, M., Delrow, J., Kim, J., Johnson, E., Doe, C.Q. (2003) Unwrapping glial biology: Gcm target genes regulating glial development, diversification, and function. Neuron, 38, 567-580 | [PDF] [Movie 1] [Movie 2]

McDonald, J.A. Fujioka, M., Odden, J.P., Jaynes, J.B., Doe, C.Q. (2003) Specification of motoneuron fate in Drosophila: Integration of positive and negative transcription factor inputs by a minimal eve enhancer. Journal of Neurobiology 57(2), 193-203 | [PDF]

Rolls, M.M. and Doe, C.Q. (2003) Cell Polarity: From embryo to axon. Nature 421, 905-906. | [PDF]

Albertson, R. and Doe, C.Q. (2003) Dlg, Scrib and Lgl regulate neuroblast cell size and mitotic spindle asymmetry. Nature Cell Biology 166-170. | [PDF] [Movie]

2002

Ryter, J.M., Doe, C.Q., Matthews, B.M. (2002) Structure of the DNA Binding Region of Prospero Reveals a Novel Homeo-Prospero Domain. Structure10, 1541-1549. | [PDF]

Odden, J., Holbrook, S., and Doe, C.Q. (2002) Drosophila HB9 Is Expressed in a Subset of Motoneurons and Interneurons, Where It Regulates Gene Expression and Axon Pathfinding. The Journal of Neuroscience | [PDF]

2001

Zelhof, A.C., Bao, H., Hardy, R.W., Zhang, B., and Doe, C.Q. (2001) Drosophila Amphiphysin is implicated in protein localization and membrane morphogenesis but not in endocytosis., Development 128, 5005-5015. | [PDF]

Freeman, M. and Doe, C.Q. (2001) Asymmetric Prospero localization is required to generate mixed neuronal/glal lineages in the Drosophila CNS. Development128, 4103-4112. | [PDF]

Isshiki, T., Pearson, B., Holbrook, S., and Doe, C.Q. (2001) Drosophila neuroblasts sequentially express transcription factors which specify the temporal identity of their neuronal progeny. Cell106, 511-521. | [PDF]

Doe, C.Q. and B.B. Bowerman. (2001) Asymmetric cell division: fly neuroblast meets worm Zygote. Current Opinion Cell Biol, 13, 68-75. | [PDF]

2000

Peng, C.-Y., L.M. Manning, R. Albertson and C.Q. Doe. (2000) The tumor suppressor genes lgl and dlg regulate basal protein targeting in Drosophila neuroblast.Nature408, 596-600. | [PDF]

Von Ohlen, T. and Doe, C.Q. (2000) Convergence of Dorsal, Dpp and Egfr signaling pathways subdivides the Drosophila neuroectoderm into three dorsoventral columns. Dev. Biol.224, 362-372. | [PDF]

Schmid, A., Chiba, A., and Doe, C.Q. (1999) Clonal analysis of Drosophila embryonic neuroblasts: neural cell types, axon projections and muscle targets. Development 126, 4653-4689. | [PDF] [Data]

Manning, L. and Doe, C.Q. (1999) Prospero distinguishes sibling cell fate without asymmetric localization in the Drosophila adult external sense organ lineage. Development 126, 2063-2071. | [PDF]

Weiss, J., Von Ohlen, T., Mellerick, D., Dressler, G., Doe, C., and Scott, M. (1998) Dorsal-ventral patterning in the Drosophila central nervous system: The intermediate neuroblasts defective homeobox gene specifies intermediate column identity. Genes & Dev. 12, 3591-3602. | [PDF]

McDonald, J.A., Holbrook, S., Isshiki, T., Weiss, J., Doe, C., and Mellerick, D. (1998) Dorsoventral patterning in the Drosophila CNS: the vnd homeobox gene specifies ventral column identity. Genes & Development. 12, 3603-3612. | [PDF]

Srinivasan, S., Peng, C.-Y., Skeath, J.B., Nair, S., Spana, E.P., Lassy, C., Doe, C.Q. (1998) Biochemical analysis of the Prospero protein during asymmetric cell division: cortical Prospero is highly phosphorylated relative to nuclear Prospero. Developmental Biology 204, 478-487. | [PDF]

Doe, C., Fuerstenberg, S. and Peng, C. (1998) Neural stem cells from fly to vertebrate. Journal of Neurobiology 36, 111-127. | [PDF]

Skeath, J.B., and Doe, C.Q. (1998) Sanpodo and Notch act in opposition to Numb to distinguish sibling neuron fates in the Drosophila CNS. Development 125, 1857-1865. | [PDF]

Broadus, J.B., Fuerstenberg, S. and Doe, C.Q. (1998) Staufen-dependent localization of prospero mRNA contributes to neuroblast daughter cell fate. Nature 391, 792-795. | [PDF]

Ikeshima-Kataoka, H., Skeath, J.B., Nabeshima, Y., Doe, C.Q., and Matsuzaki, F. (1997) Miranda directs Prospero to a daughter cell during Drosophila asymmetric divisions. Nature 390, 625-628. | [PDF]

Broadus, J.B. and Doe, C.Q. (1997) Extrinsic cues, intrinsic cues, and microfilaments regulate asymmetric localization of Prospero, Staufen, and Inscuteable in Drosophila neuroblasts. Current Biology. 7, 827-835. | [PDF]

McDonald, J.A. and Doe, C.Q. (1997) Establishing neuroblast-specific gene expression in the Drosophila CNS: huckebein is activated by wingless and hedgehog and repressed by engrailed and gooseberry. Development 124, 1079-1087. | [PDF]

Skeath, J.B. and Doe, C.Q. (1996) achaete-skute complex proneural genes contribute to neural precursor specification in the Drosophila CNS. Curr. Biol.,9, 1146-1152. | [PDF]

Spana, E.P. and Doe, C.Q. (1996) Numb antagonizes Notch signaling to specify sibling neuron cell fates. Neuron 17, 21-26. | [PDF]

Chu-LaGraff, Q., Schmid, A., Leidel, J., Bronner, G., Jackle, H., and Doe, C.Q. (1995) huckebein specifies aspects of CNS precursor identity required for motoneuron axon pathfinding. Neuron 15, 1041-1051.

Spana, E., Kopczynski, C., Goodman, C.S. and Doe, C.Q. (1995) Asymmetric localization of numb autonomously determines sibling neuron identity in the Drosophila CNS. Development 121, 3489-3494. | [PDF]

Spana, E. and Doe, C.Q. (1995) The prospero transcription factor is asymmetrically localized to the cell cortex during neuroblast mitosis in Drosophila. Development 121, 3187-3195. | [PDF]

Cui, X. and Doe, C.Q. (1995) The role of the cell cycle and cytokinesis in regulating gene expression in the Drosophila CNS. Development 121, 3233-3243. | [PDF]

Skeath, J.B., Zhang, Y., Holmgren, R., Carroll, S.B., and Doe, C.Q. (1995) Specification of neuroblast identity in the Drosophila embryonic central nervous system by gooseberry-distal. Nature 376, 427-430. | [PDF]

Broadus, J., Skeath, J.B., Spana, E.P., Bossing, T., Technau, G., Doe, C.Q. (1995) New neuroblast markers and the origin of the aCC/pCC neurons in the Drosophila central nervous system. Mechanisms of Development 53, 393-402 | [PDF]

Chu-LaGraff, Q., Doe, C.Q. (1993) Neuroblast Specification and Formation Regulated by wingless in the Drosophila CNS. Science 261, 1594-1597. | [PDF]

 

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